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Briumvi® (ublituximab-xiiy) is a monoclonal antibody therapy used to treat adults with relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. It belongs to a group of medications called anti-CD20 therapies, which are designed to target and reduce B cells — immune cells that play a major role in the body's attack on the nervous system in MS.
Briumvi is administered through intravenous (IV) infusion at our specialized infusion center. The typical infusion schedule includes:
This twice-yearly schedule provides an effective and convenient treatment option for individuals needing B-cell–depleting therapy.
The Briumvi® infusion cost can vary depending on several factors, such as your insurance plan and coverage. At Advanced Neurology Colorado, our goal is to make treatment more accessible and less stressful for every patient.
We partner with nearly all major insurance providers throughout Colorado — including Aetna, Anthem, Blue Cross Blue Shield, Cigna, Humana, UnitedHealthcare, and others — as well as Medicaid and Medicare. Our team works closely with your insurance company to ensure you receive the maximum coverage available for your Briumvi treatment.
Our dedicated infusion team provides comprehensive support to make treatment more accessible:
This removes the administrative burden from you so you can focus on your health.
In multiple sclerosis (MS), the immune system mistakenly attacks the myelin sheath — the protective layer surrounding nerve cells in the brain and spinal cord. When the myelin is damaged, nerve signals are disrupted, which can cause symptoms affecting coordination, balance, movement, speech, vision, and even bowel function.
One of the main immune cells involved in this damaging process is the B cell, which carries a marker known as CD20 on its surface. Briumvi works by:
What makes Briumvi unique among anti-CD20 therapies is its engineered structure, which allows for faster infusion times compared to some other B-cell depleting medications.
While Briumvi does not cure MS, it helps reduce inflammation and slow the disease's progression by preventing B cells from causing further attacks on the nervous system. Briumvi begins working in your body within 24 hours of the first infusion, but it typically takes several weeks to months to observe its full effect in reducing relapses and disease progression. Clinical studies demonstrating significant results evaluated patients over 96 weeks (nearly two years), with long-term data now available showing sustained benefits up to six years. Most patients can expect to see a reduction in relapse frequency and a slowing of disability progression as the medication takes full effect.
Like all medications, Briumvi can cause side effects, though not everyone experiences them. Common Briumvi infusion symptoms include:
Serious Briumvi side effects require immediate medical attention and include:
Your healthcare team will monitor you closely during and after each infusion to ensure your safety.
Our infusion center is staffed by board-certified neurologists and experienced infusion nurses (BSN-prepared and Registered Nurses) who specialize in neurological care. Together, they ensure each patient receives safe, high-quality, and compassionate infusion treatment.
Dr. Dasari, our lead neurologist, brings extensive expertise in multiple sclerosis and complex neurological conditions. With advanced training in neurology and years of dedicated experience treating MS patients, Dr. Dasari and our team of healthcare providers understand the nuances of B-cell depleting therapies like Briumvi. Our providers stay current with the latest research and treatment protocols to deliver evidence-based care tailored to each patient's unique needs.
Our clinical team is also experienced in managing a wide range of neurological conditions beyond MS, including myasthenia gravis, neuropathy, and other autoimmune neurological disorders. We utilize advanced diagnostic tools, including electromyography, to provide comprehensive neurological care under one roof.
We manage prior authorizations and benefits verification while helping patients navigate copay and foundation assistance programs. Our goal is to reduce financial stress and make therapy as affordable as possible.
A Cigna study found that patients treated in physician-owned infusion centers — like Advanced Neurology Colorado's Infusion Center — typically have much lower out-of-pocket and overall costs compared to those treated at hospital-based centers.
For 20+ years Advanced Neurology Colorado has provided specialized care for individuals with multiple sclerosis and other neurological conditions across the region. Our years of experience treating thousands of patients with complex neurological disorders have refined our clinical expertise and deepened our understanding of the challenges our patients face.
This long-standing commitment to excellence means you benefit from a team that has witnessed the evolution of MS treatments, from early disease-modifying therapies to today's advanced infusion options like Briumvi. Our established reputation and track record of successful patient outcomes make us a trusted leader in neurological care throughout Colorado.
Multiple Sclerosis
Briumvi® (ublituximab-xiiy): Approved in December 2022
TG Therapeutics, Inc.
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Billing is transparent—no surprise charges like at my last neuro."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
