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Ocrevus® (ocrelizumab) is a monoclonal antibody therapy designed to treat both relapsing forms of multiple sclerosis (RMS) and primary progressive multiple sclerosis (PPMS) in adults. It's part of the anti-CD20 therapy class, which targets and removes specific B cells — immune cells known to contribute to the nerve damage associated with MS.
What sets Ocrevus apart from many other MS treatments is its ability to address both relapsing and progressive forms of the disease, making it one of the most comprehensive treatment options available. In fact, Ocrevus is the first FDA-approved therapy for primary progressive MS, offering hope to patients who previously had limited treatment options.
Ocrevus infusion is administered intravenously at our specialized infusion center. The initial treatment involves:
Premedications (corticosteroid and antihistamine) are given before each infusion to reduce the risk of reactions. Patients are monitored for at least one hour after each infusion. For those who tolerate the treatment well, a shorter infusion option may be available for maintenance doses.
In MS, the immune system attacks the myelin sheath — the insulating layer around nerves in the brain and spinal cord that allows efficient communication between nerve cells. Damage to this sheath can disrupt nerve signals, leading to symptoms such as muscle weakness, coordination difficulties, visual disturbances, and cognitive changes.
Ocrevus works by targeting a specific type of immune cell involved in this process:
What makes Ocrevus unique is its proven effectiveness in treating both relapsing and primary progressive forms of multiple sclerosis. For relapsing MS, it significantly reduces the frequency of relapses and slows disability progression. For primary progressive MS, where symptoms steadily worsen over time, Ocrevus is the first and only treatment shown to slow the progression of physical disability.
While Ocrevus does not cure MS, it helps reduce inflammation, slow disability progression, and minimize new disease activity — supporting improved stability and quality of life. Patients can begin to see measurable effects from Ocrevus in as little as 12 weeks, with benefits continuing to increase over many months to a few years. Clinical trials have demonstrated sustained benefits over extended treatment periods, helping patients maintain function and reduce disease activity long-term.
Like all medications, Ocrevus can cause side effects. Common Ocrevus infusion side effects include:
Less common but serious side effects require immediate medical attention:
Rare but serious complications can include blood clots, heart failure, and stroke. Your healthcare team at our Fort Collins infusion center will monitor you closely during and after each Ocrevus IV infusion to ensure your safety.
The Ocrevus infusion cost depends on individual insurance coverage and benefits. At Advanced Neurology Colorado, our team works to make treatment as seamless and affordable as possible for every patient.
We collaborate with most major commercial insurance providers throughout Colorado — including Aetna, Anthem, Blue Cross Blue Shield, Cigna, Humana, and UnitedHealthcare — as well as Medicaid and Medicare. Our team works closely with your insurance company to maximize your coverage for Ocrevus treatment.
Our infusion staff provides comprehensive support to make treatment more accessible:
Our Colorado infusion center is staffed by board-certified neurologists and BSN-prepared Registered Nurses with extensive experience in neurological infusion care. Patients can expect expert oversight and compassionate, individualized support throughout treatment.
Our medical team brings specialized expertise in multiple sclerosis and complex neurological conditions. With advanced training and years of experience managing MS patients on anti-CD20 therapies, our team of healthcare providers understand the unique considerations for both relapsing and progressive MS treatment.
Our clinical expertise extends beyond MS to include comprehensive care for myasthenia gravis, neuropathy, and other neurological disorders. We have advanced diagnostic capabilities, including electromyography, to provide complete neurological care in one convenient location.
We handle prior authorizations, verify benefits, and assist patients with copay and foundation support programs to reduce financial strain.
Studies, including one from Cigna, show that patients treated in physician-owned infusion centers — such as Advanced Neurology Colorado’s Infusion Center — often pay less overall and out of pocket compared to hospital outpatient centers.
With over 20 years of service to the Colorado community, Advanced Neurology Colorado has built a reputation for excellence in the treatment of MS and other neurological disorders. Our decades of experience mean we've treated thousands of patients with both relapsing and progressive MS, giving us deep insight into the challenges you face and the most effective treatment approaches.
Our established track record with Ocrevus infusion for multiple sclerosis and other anti-CD20 therapies means you benefit from a team that understands not just the science behind the treatment, but the real-world impact on patients' lives. Our team's experience, care, and dedication continue to make a meaningful difference for patients every day.
Multiple Sclerosis
Primary Progressive Multiple Sclerosis
Ocrevus® (ocrelizumab): Approved on March 28, 2017
Genentech (a subsidiary of Roche)
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
"Billing is transparent—no surprise charges like at my last neuro."
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
