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Vyepti® (eptinezumab-jjmr) is an IV infusion treatment for adults designed to prevent migraine attacks before they start. It works by blocking calcitonin gene-related peptide (CGRP), a protein that contributes to migraine pain and inflammation in the brain. By inhibiting CGRP, Vyepti® helps reduce the frequency, intensity, and duration of migraine episodes.
Vyepti is FDA-approved for the preventive treatment of migraine in adults with both episodic migraine (fewer than 15 headache days per month) and chronic migraine (15 or more headache days per month). It's particularly beneficial for patients who have not found adequate relief with or cannot tolerate oral preventive medications.
What makes Vyepti unique among migraine preventive treatments is its delivery method and dosing schedule. Unlike oral CGRP medications that require daily pills or injectable CGRP inhibitors that require monthly self-injections, Vyepti is administered as an IV infusion just once every 3 months at a healthcare facility. This quarterly schedule offers superior convenience and ensures consistent medication delivery without the burden of daily or monthly dosing.
Vyepti infusion is administered at our specialized infusion center. The treatment details include:
Vyepti Infusion Frequency and Schedule:
Dosing Options:
Vyepti IV Infusion Duration:
Migraine is a complex neurological condition involving abnormal brain activity, inflammation, and changes in blood flow. Research has identified calcitonin gene-related peptide (CGRP) as a key player in triggering and sustaining migraine attacks. CGRP levels spike during migraines, causing:
Vyepti works through a targeted mechanism:
What sets Vyepti apart from other CGRP inhibitors is its intravenous delivery and rapid action. Because it's administered directly into the bloodstream, Vyepti achieves immediate therapeutic levels without relying on oral absorption or subcutaneous injection. This allows for faster onset of action compared to other CGRP treatments.
While Vyepti doesn't cure migraines, it's a preventive therapy that can dramatically reduce the occurrence and severity of migraine attacks over time, helping patients regain control of their lives and reduce their reliance on acute migraine medications.
Common Vyepti infusion side effects are generally mild and may lessen as your body adjusts:
Serious Vyepti infusion side effects require immediate medical attention. Vyepti can cause hypersensitivity reactions, including life-threatening allergic responses. Seek emergency help if you experience:
Your healthcare team will monitor you during and after each infusion for any signs of allergic or hypersensitivity reactions to ensure your safety.
The Vyepti infusion cost depends on insurance coverage and provider. At Advanced Neurology Colorado, we're dedicated to improving access and affordability for all our patients seeking effective migraine prevention.
We work with most major insurance plans throughout Colorado, including Aetna, Anthem, Blue Cross Blue Shield, Cigna, Humana, and UnitedHealthcare, along with Medicaid and Medicare.
Our infusion staff provides comprehensive support to make treatment more accessible:
Our infusion center is led by board-certified neurologists and supported by a team of BSN-prepared Registered Nurses who specialize in neurological infusion care. Our team has extensive experience treating patients with both episodic and chronic migraine.
Our approach to migraine treatment includes:
Beyond migraine care, our comprehensive neurological expertise extends to multiple sclerosis, myasthenia gravis, neuropathy, and other conditions.
We help patients handle insurance paperwork and access copay and foundation assistance to make treatment more affordable.
A Cigna report recently found that infusions at physician-owned centers like Advanced Neurology Colorado’s Infusion Center often result in lower overall costs than at hospital outpatient centers.
Our decades of experience treating complex neurological conditions means we understand how debilitating chronic migraines can be and how transformative effective preventive treatment can be for our patients.
Our established reputation and commitment to staying current with the latest migraine treatments, including innovative therapies like Vyepti, give patients confidence they're receiving cutting-edge care from an experienced team.
Migraine
Migraine: Approved on February 22, 2020
Lundbeck Inc.
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"Billing is transparent—no surprise charges like at my last neuro."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
“Amazing. I have been with other Doctors at this practice as well but I had an amazing experience with Dr. Lackey specifically. Very attentive and friendly to work with! Highly recommend!”
"No-nonsense. Dr. Dasari's neuropathy staging system helped us prioritize treatments."
"Migraine magician - Botox + Nurtec combo cut my headache days from 25/month to 4. His headache diary app makes tracking effortless."
“Dr. Dasari has been a God-send for my MS. He is incredibly knowledgeable and makes me feel heard. He allocates his time for me as a patient and I know I couldn’t manage this disease without him!”
"Brutally honest - Wish she'd sugarcoat less, but her MG treatment plan stopped my hospitalizations. Clinical trials access is a plus."
"MG crisis hero - Got me into the hospital for IVIG within 4 hours during a bulbar crisis. Her fellow even checked on me at midnight."
"ALS guardian - Coordinates with my pulmonologist, PT, and speech therapist in one shared portal. Her ALS Functional Rating Scale checks keep us proactive."
“Dr. Yang is nothing but amazing! She has helped me so much with a diagnosis that moved my world upside down. She treats my almost daily migraines as well. She and her team will do what they can to get me the medication I need! She is very compassionate and kind!”
"Spotless floors, sanitizer everywhere, and masks required. Felt very safe."
"Courtney Weir is an amazing medical professional! She is thorough and addresses all my questions. Each visit she remembers not only me, but asks about my family - above and beyond client care. I love having her, best provider by far! Can't recommend her enough."
"I feel confident knowing I'm in capable hands and truly appreciate the thoughtful, attentive care Dr. Dasari provides. I highly recommend him to anyone seeking comprehensive and compassionate neurological care."
"The MA Jess noticed I was anxious and brought me a weighted blanket. Above and beyond!"
"Billing is transparent—no surprise charges like at my last neuro."
"ANC’s telehealth option saved me a 2-hour drive. Seamless tech setup!"
"The only neurology clinic I’ve been to where you don’t feel like just a number."
"ANC runs like a well-oiled machine. Appointments start on time, and the staff remembers me every visit."
